Like their human caretakers, dogs and cats can develop motion sickness when their inner ear's delicate balance mechanism is thrown off-kilter [source: American Kennel Club]. In 2007, the Food and Drug Administration approved the very first anti-nausea treatment for dogs, Pfizer's Cerenia, which can be injected or given orally [source: Herndon].
Cerenia works by blocking your dog's urge to vomit, and the drug can be given with a small amount of food [source: Higgins].
You'll know your pet is nauseated when it begins to drool, act skittish or even develop diarrhea. Unfortunately, your kitty won't respond to antihistamines because it lacks the histamine receptor needed to make this type of medication work. Instead, talk to your vet about phenobarbital or chlorpromazine to block potential vomiting [source: Merck].
Besides the mess caused by a sick pet (or two), the biological stress of vomiting can take its toll on your four-legged companion. Animals that vomit for long periods of time can become dehydrated. This can lead to death in extreme cases. You don't want to deprive your animal of water, but remember that pets will travel better on an empty stomach [source: Drs Foster and Smith].
You shouldn't lose sleep over traveling with pets, but make sure you employ extra caution when using sedatives. You'll learn why in our next section.