How Rabies Works


Rabies Prevention and Treatment

Effective rabies prevention really just comes down to knowing what to look for. Good judgment and common sense are paramount to staying rabies-free. Rabies is a deadly disease, but most people go their entire lives without running into a rabid animal, so it can be avoided. However, if treatment becomes necessary, the rabies vaccine is still the principal, and only, line of defense.

Pasteur's vaccine relied on an attenuated, or weakened, form of the rabies virus gathered from the spinal cords of infected animals. By applying a series of vaccinations of increasingly potent forms of the virus over several days, Pasteur found he could inoculate animals to the disease. By slowly introducing the virus, Pasteur allowed the body to build up a resistance, so by the time the disease reached the central nervous system the body had developed an immunity to it [source: Cohn].

The vaccine we use today follows the same concept but is much less dangerous. Pasteur developed a live-attenuated vaccine, or an alive but weakened form of the virus. Today, we use an inactivated vaccine, or vaccine that is already dead. Immunity can still be built up using a dead virus, though it often doesn't last as long as a live-attenuated vaccine. There are also fewer side effects with an inactivated vaccine.

Both people and pets can be pre-emptively vaccinated for rabies. For pets in the U.S., it's often a crime not to do so, though that is not yet true in all states. Some people with a high risk for contracting the disease are often encouraged to be vaccinated before they become exposed. Veterinarians, spelunkers, some lab technicians and individuals who frequently travel to rabies hot spots around the globe often receive regular rabies shots as a precautionary measure.

Now that you're well-versed in all things rabies, check out the links below to learn more about other gruesome but compelling sicknesses and diseases such as the bubonic plague and avian flu.

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  • animalhealthchannel. "Rabies: Signs and Symptoms." 2009. (01/16/2009)http://www.animalhealthchannel.com/rabies/symptoms.shtml
  • Associated Press. "Rabies Survivor Viewed as 'Medical Marvel.'" Foxnews.com. 08/31/2007. (01/25/2009)http://www.foxnews.com/story/0,2933,295098,00.html
  • BBC. "Girl Survives Rabies Without Jab." 11/25/2004. (01/21/2009)http://news.bbc.co.uk/1/hi/health/4042005.stm
  • Blanton, Jesse D., Cathleen A. Hanlon, and Charles E. Rupprecht. "Public Veterinary Medicine: Public Health : Rabies Surveillance in the United States during 2006." Center for Disease Control. 08/15/2007. (01/16/2009)http://www.cdc.gov/rabies/docs/rabies_surveillance_us_2006.pdf
  • Brown, C.F. Wemyss. (1910). "St. Hubert." The Catholic Encyclopedia. 2009. (01/24/2009)http://www.newadvent.org/cathen/07507a.htm
  • Centers for Disease Control and Prevention. "MMWR." 08/05/1998. (01/27/2009)http://www.cdc.gov/mmwr/preview/mmwrhtml/00001393.htm
  • Centers for Disease Control and Prevention. "Epidemiology: United States Rabies Surveillance Data, 2006." 09/18/2007 (01/17/2009)http://www.cdc.gov/rabies/epidemiology.html
  • Centers for Disease Control and Prevention. "Rabies." 10/08/2008. (01/16/2009)http://www.cdc.gov/rabies/
  • Cohn, David V. "The Life and Times of Louis Pasteur." 02/11/1996. (01/16/2009)http://louisville.edu/library/ekstrom/special/pasteur/cohn.html
  • De Suriyani. "Bali Set to be Rabies-free Within a Year." The Jakarta Post. 12/15/2008. (01/19/2009)http://www.thejakartapost.com/news/2008/12/15/bali-set-be-rabiesfree-within-a-year.html
  • Gibbons, Robert V., Robert C. Holman, Stephen R. Mosberg, and Charles E. Rupprecht. "Knowledge of Bat Rabies and Human Exposure Among United States Cavers." Centers for Disease Control. 08/13/2002. (02/05/2009)http://www.cdc.gov/ncidod/eid/vol8no5/01-0290.htm
  • Hartocollis, Anemona. "Rabid Pet is Among Dogs Flown Here From Iraq." The New York Times. 10/02/2008. (02/06/2009)http://www.nytimes.com/2008/10/03/nyregion/03rabies.html?_r=1&scp=1&sq=Crusader%20dog&st=cse
  • Jackson, Alan C., and William H. Wunner, Ed. "Rabies." Academic Press. 2002. (02/04/2009)http://books.google.com/books?id=p8rMezRaD4oC&pg=PA255&lpg=PA255&dq=rabies+afferent&source=bl&ots=JbLYD8xhA4&sig=cRtih-6C8P7AIlr6m5sVK4eCN8Q&hl=en&sa=X&oi=book_result&resnum=5&ct=result
  • Judson, Olivia. "A Coffin for Rabies." The New York Times. 01/15/2008. (01/20/2009)http://judson.blogs.nytimes.com/2008/01/15/a-coffin-for-rabies/
  • Kidshealth.org. "Infections: Rabies." 06/2008. (01/15/2009)http://kidshealth.org/parent/infections/bacterial_viral/rabies.html
  • McPhee, Stephen J., and Maxine A. Papadakis. "2007 Current Medical Diagnosis & Treatment." "Rabies." McGraw Hill. 2007.
  • Merck Veterinary Manual, The. "Rabies: Introduction." 2008. (02/05/2008)http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/102300.htm
  • Michigan Department of Natural Resources. "Rabies." 2007. (02/04/2009).http://www.michigan.gov/dnr/0,1607,7-153-10370_12150_12220-27259--,00.html
  • New York State Department of Health. "State Rabies and Animal Control Statutes." 05/2006. (01/26/2009)http://www.health.state.ny.us/diseases/communicable/zoonoses/rabies/phlrab.htm
  • North Dakota Department of Health Rabies Program. "Questions and Answers about Rabies." 2006.http://www.ndhealth.gov/disease/Rabies/QandA.htm
  • RabiesFreeWorld.org. "A Short History of Rabies." 2007. (01/16/2009)http://www.rabiesfree.org/page26.htm
  • Ray, Claiborne C. "Q&A; Rodents and Rabies" New York Times. 07/10/2001. (01/23/2009)http://query.nytimes.com/gst/fullpage.html?res=9802E4D61038F933A25754C0A9679C8B63
  • Rupprecht, Charles and Matthew Reynolds. "A Cup of Health with CDC: Preventing Rabies." Centers for Disease Control and Prevention. 04/13/2007. (01/16/2009)http://www2a.cdc.gov/podcasts/media/pdf/mmwr5_041307_transcript.pdf
  • Sime, David. "Rabies: Its Place Amongst Germ-diseases, and Its Orgin in the Animal Kingdom." Harvard University Press. 1903. (01/23/2009)http://books.google.com/books?id=Ug0pAAAAYAAJ&pg=PA37&lpg=PA37&dq=rabies+afferent+nerves&source=bl&ots=DmKr-NIJOH&sig=w3lNnYX42wMAMev1Z6zJXTQy0EA&hl=en&sa=X&oi=book_result&resnum=1&ct=result
  • Steele, James H., and Peter J. Fernandez. "The Natural History of Rabies and Global Aspects." 2009. (01/21/2009)http://books.google.com/books?id=dw8qW6jcfWUC&pg=PA1&lpg=PA1&dq=french+word+for+rabies&source=web&ots=CkAP0a71kK&sig=fqG3RGk3JFBBP1VcDg-amYkLQ2U&hl=en&sa=X&oi=book_result&resnum=1&ct=result
  • Town of Orleans. "Massachusetts Wildlife Rabies Vaccination Project." No Date Given. (01/23/2009)http://orleansma.virtualtownhall.net/Pages/OrleansMA_Health/rabiesfall08faq.pdf
  • Hingley, Audrey. "Rabies on the Rise." U.S. Food and Drug Administration. 11/1996. (01/25/2009).http://www.fda.gov/FDAC/features/996_rab.html
  • WebMD. "Rabies Topic Overview." 09/16/2006. (01/15/2009)http://www.webmd.com/a-to-z-guides/rabies-topic-overview
  • Williams, Elizabeth S., and Ian K. Barker. "Infectious Diseases of Wild Mammals." 3rd Edition. 2001. (Jan 21, 2008)http://books.google.com/books?id=I62ZO_4cjwC&pg=PA4&lpg=PA4&dq=ancient+rabies+cases&source=web&ots=bHhv136QGB&sig=H6cyvSVk2A0HuwVQK58E3c_Td-s&hl=en&sa=X&oi=book_result&resnum=5&ct=result#PPA4,M1
  • World Health Organization. "Rabies." 2009. (01/16/2009).http://www.who.int/rabies/en/
  • World Health Organization. Rabies Fact Sheet. December 2008.http://www.who.int/mediacentre/factsheets/fs099/en/index.html
  • World Health Organization. "Rabies and Envenomings: A Neglected Public Health Issue: A Report of a Consultative Meeting." 01/10/2007. (01/16/2009)http://www.who.int/bloodproducts/animal_sera/Rabies.pdf

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