How could New York not make our list? There are almost as many activities for pets as there are for humans in this city that never sleeps.
However, if you do want to sleep at some point during your stay, you'll find no shortage of pet-friendly hotels. One hotel even offers rental pets. The Soho Grand Hotel will provide a complimentary goldfish to keep you company if you've left your own best friend at home. The Muse Hotel in the theater district offers a Pampered Pooch Package for smaller dogs. The hotel is home to what it claims is the only doggy playground in New York -- a "Canine Court" complete with its own obstacle course.
You can take your best friend along while you tour the city's attractions. New York Dog Tours offers three different doggy-and-me excursions -- to Central Park and the West Side, Midtown and Downtown. On hot summer days, dogs can cool off at the man-made swimming pond in Brooklyn's Prospect Park. Your pets can even escort you on a spending spree through some of the city's most elegant department stores, including Saks Fifth Avenue, Ralph Lauren and Tiffany's.